DMAE may aid in the treatment of ADHD and other disorders

DMAES-4030 DMAE

DMAE 100 capsules

DMAE may aid in the treatment of ADHD and other disorders affecting the brain and central nervous system.

DMAE, or dimethylaminoethanol, is a compound found in high levels in anchovies and sardines. Small amounts of it are also naturally produced in the human brain. Health-food outlets sell it in capsule form to "boost brain power." It probably won't make you smarter, but some evidence suggests it may have benefits against the impulsive and disruptive behaviors caused by attention deficit hyperactivity disorder (ADHD). It may also have a role in treating memory lapses and Alzheimer's disease, as well as some troubling movement disorders.

The supplement has an interesting history. Initially, drug makers were interested in selling the product as a medication for attention deficit disorder when studies in the 1970s showed that deanol, the chemical name for DMAE, reduced hyperactivity and improved concentration in schoolchildren with learning disabilities and behavior problems. However, when further testing was deemed too expensive, it was packaged as a nutritional supplement, since this substance is naturally found in fish.

Health Benefits
Because it steps up production of brain chemicals essential for short-term memory, concentration, and learning capacity, DMAE may aid in the treatment of ADHD and other disorders affecting the brain and central nervous system.

DMAE is sometimes referred to as a "cholinergic" because it is thought to increase levels of the neurotransmitter acetylcholine, one of the chemicals in the brain that enhances mental powers. "Cholinergic" drugs, such as tacrine (Cognex), are used to treat the dementia of Alzheimer's disease.

Cholinergic drugs are also sometimes prescribed to stabilize the debilitating movements brought on by tardive dyskinesia, a heartbreaking side effect of the antipsychotic drugs used to treat schizophrenia, and Huntington's chorea, an inherited condition that also causes memory loss. Researchers have tested DMAE for these conditions, although results of several small studies have been disappointing. Still, case reports continue to report some benefits for DMAE in certain individuals with these movement disorders. Any benefits, if present, may be due to a placebo effect or some unknown factor that makes certain people particularly responsive to the supplement.

Marketers have also trumpeted DMAE pills and creams for everything from prolonging life and enhancing athletic performance to ridding aging skin of "liver spots." However, there are no sound studies to support these claims. Moreover, there is no evidence that human beings can suffer from a deficiency of DMAE.

Specifically, DMAE may help to:
" Relieve the inattention, impulsivity, and hyperactivity of attention deficit hyperactivity disorder (ADHD). Although ADHD has long been recognized as a cause of disruptive behavior and learning difficulties in school-age children, doctors are increasingly coming to recognize it as a cause of problems in adults as well.

Evidence suggests that DMAE may help.
Studies done in children in the 1970s form the basis for DMAE's role in treating ADHD. One trial assessed 50 hyperactive kids who would likely be diagnosed with ADHD based on current standards. After 10 weeks, DMAE produced improvements in behavior compared to a placebo. In another study, children with learning disabilities were given DMAE, the stimulant Ritalin (methylphenidate, the most commonly prescribed drug for ADHD), or a dummy pill. Those who were given either DMAE or Ritalin showed objective improvements on concentration and skills tests.

Some recent research points to deficits in short-term, or working, memory in both children and adults with ADHD (although long-term memory is fine in these patients). Some of DMAE's possible benefits for ADHD may therefore be due to its memory-boosting potential. Studies have yet to confirm this effect, however.
" Slow the progressive dementia of Alzheimer's disease. The severe and progressive memory loss of Alzheimer's disease is due in part to the loss of brain cells that produce acetylcholine, a key chemical messenger for enhancing communication between brain cells. Acetylcholine is also essential for learning and memory. In fact, it's for these reasons that doctors routinely prescribe drugs that boost levels of acetylcholine, such as tacrine (Cognex), donepezil (Aricept), rivasatigmine (Exelon), and galantamine (Reminyl).

In animal studies, DMAE supplements have led to significant improvements in short-term memory, possibly due to cholinergic effects. A number of small studies indicate that DMAE may have similar benefits for people with Alzheimer's.

Not all studies have been positive, however. In one trial, when researchers compared DMAE to a placebo in 27 Alzheimer's patients, the DMAE supplements provided no benefit. In fact, nearly half of the patients stopped taking DMAE due to unpleasant side effects such as drowsiness and increased confusion. Other research investigating whether DMAE is truly a precursor of acetylcholine has been mixed as well, calling into question the supplement's effectiveness for Alzheimer's and other memory disorders.

Improve memory. The possible memory-boosting effects of DMAE may help with the ordinary memory lapses that occur with normal aging. Many nutritionally oriented physicians prescribe DMAE along with another memory enhancer, the dietary supplement phosphatidylcholine. Although rigorous studies are lacking, some people who have tried DMAE report better memory (especially short-term memory), as well as improved concentration, focus, mental clarity, and sleep.

Supplement Facts
100 Capsules per Bottle
SUGGESTED USE: As a dietary supplement take 1 to 2 capsules per day with water or juice.

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Item Number: DMAES-4030 Quantity:

Statements on this site have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, prevent, treat, cure or prevent any disease. Please consult a qualified healthcare practitioner for medical advice.

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